msGUIDE has officially started on April 1st, 2022. The goal of msGUIDE is to develop a highly sensitive novel imaging technology consisting of a Near-Infrared Fluorescence and Reflectance Multispectral Imaging (NIR-FRMI) unit integrated into a never before seen High-definition White Light Endoscope (HD-WLE) to quantify drug distribution and concentration and identify the individual drug target cells in the gut.